When I build Monodevelop against the MacPort libraries it looks as follows:
As you can see you lose the 'nice' mac-like look and feel and it looks like the first version of Monodevelop that I built that, although this time I don't need X11. So because of this, I have recently taken to building against the libraries that come with the Mono Mac installer. By exporting the library path variables:
export DYLD_FALLBACK_LIBRARY_PATH=/Library/Frameworks/Mono.framework/Libraries:$HOME/lib:/usr/local/lib:/lib:/usr/lib:$DYLD_FALLBACK_LIBRARY_PATH
I found out about this from a comment by Arjan Timmerman on Bart's blog although this currently seems to be down.